MAKROLIFE
BIOTECH
USING NATURAL IMMUNITY TO FIGHT CANCER
MACROPHAGE REPOLARIZATION
IMMUNE SYSTEM PROGRAMMING FOR AN OPTIMIZED HEALING PROCESS
The word macrophage comes from the Greek terms “makro” meaning big and “phagein” meaning eat. Macrophages are a important key players in our immune system with the ability to induce multiple immune responses and to selectively target and destroy tumor cells.
Makrolife Biotech uses these qualities to develop life-changing innovative cancer therapies.
Macrophages are an essential asset in our body, especially our innate immune response. In a healthy state, the tissue-resident macrophages are sufficient to maintain homeostasis, whereas during inflammation recruitment of monocytes is necessary for covering the immune response.
"A macrophage polarization refers to how a macrophage is activated at a given point in space and time by the microenvironment."
PETER J MURRAY, 2017, Departments of Infectious Diseases and Immunology
Makrolife Biotech Small Molecules are developing an artificial microenvironment, which allows the monocytes and macrophages to transform into a specific anti-tumoral phenotype
MACROPHAGES
Macrophages are mainly involved in diverse immune molecular functions. The activation by different stimuli generates macrophages of different polarization with a spectrum of diverse purposes and functions.
The two known subgroups of macrophage polarization are the M1 and M2 polarization states. M1 macrophages are also called classically activated macrophages and feature pro-inflammatory effects, whereas M2 polarization leads to the alternatively activated anti-inflammatory state.
At Makrolife Biotech, we are advancing a new class of cancer immunotherapies to stimulate the conversion of immunosuppressive and pro-tumorigenic M2 macrophages into pro-inflammatory anti-tumoral M1 macrophages with an high efficient anti-tumoral immune response. This transformation, called macrophage repolarization, induces a coordinated immune response to fight cancer.
THE POWER OF NATURAL MACROPHAGES
Our innovative approach has the potential to develop life-changing cellular therapies for cancer patients. We harness the natural power of macrophages by manipulating them to attack tumors. Our programmed anti-tumor macrophages can kill tumor cells and lead to long-term anti-tumor immunity, offering patients a promising new long-term strategy in the fight against cancer.
We create highly efficient and durable cell therapies through the permeating power of our regulated macrophages.
Developing a New Class of Cancer Immunotherapies
Macrophages are the highest instance of our immune system and are as powerful immune cells responsible for each immune response. These hyper-flexible cells can trigger more than 1000 different responses.
At Makrolife Biotech, we harness the endless possibilities of our immune system and immune cells through re-programmed repolarised macrophages that trigger a strong and targeted anti-tumor immune response.
MACROPHAGE IMMUNOTHERAPY
We create highly efficient and durable cell therapies through the permeating power of our regulated macrophages. We are leveraging the natural power of monocytes and macrophages by manipulating them to attack tumors. Makrolife Biotech Small Molecules controlled macrophages can eliminate tumors tissue and lead to long-term anti-tumor immunity, giving patients a promising new long term strategy in the fight against cancer.
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