MAKROLIFE
BIOTECH

USING NATURAL IMMUNITY TO FIGHT CANCER

MACROPHAGE REPOLARIZATION

IMMUNE SYSTEM PROGRAMMING FOR AN OPTIMIZED HEALING PROCESS

Macrophages are an essential asset in our body, especially our innate immune response. In a healthy state, the tissue-resident macrophages are sufficient to maintain homeostasis, whereas during inflammation recruitment of monocytes is necessary for covering the immune response.

Macrophages play an important role in angiogenesis, matrix remodeling, cell regeneration and wound healing. Various signaling agents make it possible to repolarize macrophages and produce optimized gene activity. Each disease has a specific gene profile, which Makrolife Biotech uses for macrophage repolarization to ensure an optimized healing process for solid cancer types.

"A macrophage polarization refers to how a macrophage is activated at a given point in space and time by the microenvironment."

PETER J MURRAY, 2017, Departments of Infectious Diseases and Immunology

Makrolife Biotech Small Molecules are developing an artificial microenvironment, which allows the monocytes and macrophages to transform into a specific anti-tumoral phenotype

MACROPHAGES

Macrophages are mainly involved in diverse immune molecular functions. The activation by different stimuli generates macrophages of different polarization with a spectrum of diverse purposes and functions.

The two known subgroups of macrophage polarization are the M1 and M2 polarization states. M1 macrophages are also called classically activated macrophages and feature pro-inflammatory effects, whereas M2 polarization leads to the alternatively activated anti-inflammatory state.

Makrolife Biotech regulates between M1 and M2 polarization state in macrophages leading to an optimized healing process

THE POWER OF NATURAL MACROPHAGES

Our innovative approach has the potential to develop life-changing cellular therapies for cancer patients. We harness the natural power of macrophages by manipulating them to attack tumors. Our programmed anti-tumor macrophages can kill tumor cells and lead to long-term anti-tumor immunity, offering patients a promising new long-term strategy in the fight against cancer.

MACROPHAGE IMMUNOTHERAPY

By using macrophages with our Small Molecules, we can target and activate natural killer cell signaling pathways to directly target tumorcells. At the same time, our treated macrophages allow us to control and regulate processes such as angiogenesis, oxygen demand, wound healing, inflammation within the tumor.

THE POWER OF MANIPULATED MACROPHAGES

Macrophages are the highest instance of our immune system and are as powerful immune cells responsible for each immune response. These hyper-flexible cells can trigger more than 1000 different responses.

At Makrolife Biotech, we harness the endless possibilities of our immune system and immune cells through re-programmed repolarised macrophages that trigger a strong and targeted anti-tumor immune response.

MAKROLIFEBIOTECH